ABSTRACT
Background: Hypertension is a common, asymptomatic, readily detectable disease that leads to lethal complications if left untreated. Vascular inflammation may be involved in both the initiation and development of hypertension that is evident from the elevated levels of inflammatory markers like Tumor necrosis factor-α, Interleukin-6 and C-reactive protein (CRP) found in people with hypertension with no evidence of cardiovascular disease. hsCRP is associated with an increased risk of incident hypertension at all baseline blood pressures and among individuals without traditional coronary heart disease risk factors. Objectives: The present cross-sectional study was an attempt to evaluate the relationship of serum hsCRP levels and serum Lipid profile in prehypertensives and hypertensive. Material & methods: The study group included thirty diagnosed cases of prehypertension and hypertension each, attending medicine OPD at a tertiary care hospital. A healthy group of normotensive volunteers were taken as controls. Fasting blood samples were collected for measurement of serum lipid profile and hsCRP (by CLIA).Results: There was statistically significant rise in hsCRP levels in hypertensives as compared to controls and normotensives (p<0.001). The concentration of cholesterol, triglycerides and LDL-C were significantly high in hypertensives as compared with normotensives (p<0.001). Conclusion: Findings of higher levels of hsCRP in hypertension along with atherogenic lipid profile suggests that elevated hsCRP and hypertension can be independent determinants of cardiovascular risk.
ABSTRACT
Background: It is well known that Thyroid Hormones play a key role in regulating energy homeostasis. The association between thyroid hormones and energy expenditure is well established. There is inverse relationship between obesity and energy expenditure. There is a limited data on thyroid function in euthyroid obese young individuals. Objectives: The present study was designed to evaluate the relationship between thyroid function and obesity in euthyroid young individuals. Materials & Methods: Obesity was defined as per Body Mass Index. (BMI)Undergraduate medical students were grouped as normal, overweight and obese as per their Body Mass Index Thyroid function was assessed by measuring fT3, fT4 and TSH levels by using automated chemiluminescence immunoassay system. Results: We found that the levels of TSH showed significant increase in overweight and obese subjects (p< 0.001) however there was no statistical difference in the levels of fT3and fT4 in overweight and obese students as compared to normal(p> 0.05). Interpretation & Conclusion: Our results suggest that thyroid function though within the normal range could be one of several factors acting in concert to determine body weight in a population. Even slightly elevated serum TSH levels are associated with an increase in BMI.